Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 17/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375545 | 0.92 | HTR7 (0.54) | HTR7MAPTSLC2A1NPSR1L3MBTL1 | |
| SCHEMBL4375523 | 0.92 | HTR7 (0.56) | HTR7MAPTSLC2A1NPSR1L3MBTL1 | |
| SCHEMBL7006351 | 0.84 | HTR7 (0.61) | HTR7MAPTNPSR1ADRA1DADRA1A | |
| SCHEMBL7013657 | 0.83 | HTR7 (0.48) | HTR7MAPTSLC2A1NPSR1L3MBTL1 | |
| SCHEMBL4381740 | 0.83 | HTR7 (0.49) | HTR7MAPT | |
| SCHEMBL4375683 | 0.81 | HTR7 (0.56) | HTR7MAPTSLC2A1NPSR1 | |
| SCHEMBL4376845 | 0.77 | HTR7 (0.76) | HTR7SLC2A1ADRA1DADRA1AADRA1B | |
| SCHEMBL4374516 | 0.76 | HTR7 (0.51) | HTR7MAPTSLC2A1NPSR1L3MBTL1 | |
| SCHEMBL4375490 | 0.74 | HTR7 (0.69) | HTR7MAPTADRA1DADRA1AADRA1B | |
| SCHEMBL13329874 | 0.72 | LMNA (0.66) | HTR7MAPTSLC2A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | claimed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | claimed |