Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 16/20 | 0.81 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MYLK | Q15746 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005317 | 0.90 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4376845 | 0.86 | HTR7 (0.76) | HTR7ADRA1DADRA1AADRA1BCLK4 | |
| SCHEMBL4382987 | 0.83 | HTR7 (0.83) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4380313 | 0.80 | HTR7 (0.76) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4382777 | 0.79 | HTR7 (0.70) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL4540550 | 0.78 | HTR7 (0.73) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7013758 | 0.77 | HTR7 (0.71) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7006812 | 0.76 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7011314 | 0.76 | HTR7 (1.00) | HTR7ADRA1DADRA1AADRA1BHTR2C | |
| SCHEMBL7009556 | 0.76 | HTR7 (0.74) | HTR7ADRA1DADRA1AADRA1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | claimed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | claimed |