Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.62 |
| ▸ | CDC7 | O00311 | 7/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.50 |
| ▸ | NEK2 | P51955 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939866 | 0.80 | CAMKK2 (0.76) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL1666076 | 0.78 | BRD4 (0.63) | CAMKK2CDC7CAMKK1DYRK1AFLT3 | |
| SCHEMBL1665897 | 0.78 | CAMKK2 (0.61) | CAMKK2CDC7CAMKK1DYRK1AFLT3 | |
| SCHEMBL8939859 | 0.77 | CAMKK2 (1.00) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL7053843 | 0.77 | CAMKK2 (0.63) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL30563455 | 0.77 | NUDT1 (0.67) | CAMKK2CDC7PIM1CDK2DYRK1B | |
| SCHEMBL15397131 | 0.77 | DYRK1A (0.61) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL29775980 | 0.75 | CDC7 (0.59) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL26931341 | 0.75 | CDC7 (0.59) | CAMKK2CDC7CLK4ROCK2PIM1 | |
| SCHEMBL3330981 | 0.74 | CDC7 (0.72) | CAMKK2CDC7CLK4ROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |