Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.63 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CDC7 | O00311 | 3/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30563455 | 0.86 | NUDT1 (0.67) | CAMKK2NUDT1MAP2K1NEK2PLK1 | |
| SCHEMBL7548964 | 0.84 | ALDH1A1 (0.56) | CAMKK2PDPK1CDK5CDK5R1PIM1 | |
| SCHEMBL586850 | 0.82 | MAP2K1 (0.67) | CAMKK2NUDT1MAP2K1NEK2CDK2 | |
| Water SCHEMBL15530974 | 0.80 | MAP2K1 (0.65) | CAMKK2NUDT1MAP2K1NEK2PLK1 | |
| Hydrochloric Acid SCHEMBL5263201 | 0.80 | MAP2K1 (0.65) | CAMKK2NUDT1MAP2K1NEK2CDK2 | |
| SCHEMBL1820660 | 0.78 | ADORA2A (0.61) | CAMKK2NUDT1MAP2K1NEK2PLK1 | |
| SCHEMBL4374583 | 0.77 | CAMKK2 (0.62) | CAMKK2RPS6KA5NEK2PLK1CDK2 | |
| SCHEMBL8939859 | 0.77 | CAMKK2 (1.00) | CAMKK2MAP2K1RPS6KA5NEK2PLK1 | |
| SCHEMBL30320851 | 0.76 | CAMKK2 (0.55) | CAMKK2MAP2K1RPS6KA5CDK2CDC7 | |
| SCHEMBL5618155 | 0.76 | TGFBR1 (0.71) | CAMKK2MAP2K1RPS6KA5CDK2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |