Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374944 | 0.75 | HTR6 (0.60) | HTR6PTGDR2PTGDRMAPTPTGS1 | |
| SCHEMBL5331999 | 0.74 | HTR6 (0.51) | HTR6PTGDR2PTGDRMAPTPOLB | |
| SCHEMBL5332004 | 0.72 | HTR6 (0.58) | HTR6PTGDR2PTGDR | |
| SCHEMBL29839894 | 0.71 | GRIK2 (0.53) | HTR6PTGDR2PTGDRMAPTPTGS1 | |
| SCHEMBL3566087 | 0.71 | HTR6 (0.60) | HTR6PTGDR2PTGDR | |
| SCHEMBL29839943 | 0.70 | GRIK2 (0.55) | HTR6MAPTPOLBPSEN1PSEN2 | |
| SCHEMBL5332897 | 0.70 | HTR6 (0.51) | HTR6PTGDR2PTGDR | |
| SCHEMBL18222517 | 0.69 | HTR6 (0.56) | HTR6PTGDR2PTGDR | |
| SCHEMBL18239754 | 0.69 | HTR6 (0.57) | HTR6PTGDR2PTGDRPOLB | |
| SCHEMBL1888939 | 0.69 | HTR6 (0.64) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006089-A2 | A2 ADENOSINE RECEPTOR AGONISTS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-01-08 | — | — | WO | disclosed |