SCHEMBL437500

SCHEMBL437500

CCOC(=O)CC(c1ccccc1)c1ccc(OCc2ccc(OCC(=NOC)c3ccccc3)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 6/20 0.58
L3MBTL1 Q9Y468 2/20 0.43
LMNA P02545 1/20 0.43
NR1H4 Q96RI1 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 3/20 0.42
RAB9A P51151 2/20 0.42
HTT P42858 2/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
NPC1 O15118 1/20 0.41
MAPK1 P28482 1/20 0.41
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
ALOX5 P09917 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL437499 1.00 FFAR1 (0.58) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL435054 0.91 FFAR1 (0.57) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL435055 0.91 FFAR1 (0.57) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL433313 0.89 FFAR1 (0.66) FFAR1L3MBTL1SMN1; SMN2ALDH1A1HTT
SCHEMBL433312 0.89 FFAR1 (0.66) FFAR1L3MBTL1SMN1; SMN2ALDH1A1HTT
SCHEMBL10261550 0.89 FFAR1 (0.66) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL15239455 0.88 FFAR1 (0.54) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL437237 0.88 FFAR1 (0.54) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL437238 0.88 FFAR1 (0.54) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2
SCHEMBL435031 0.85 FFAR1 (0.57) FFAR1L3MBTL1LMNANR1H4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237571-A1 AGONISTS OF GPR40 GPR65, GPR55, GPR68 FFAR1 24/4885L3MBTL1 4507/4885LMNA 3516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.