Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 3/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376888 | 0.87 | TRPM8 (0.46) | ACKR3 | |
| SCHEMBL4376910 | 0.86 | SCN2A (0.52) | SCN2ASCN10ASMN1; SMN2 | |
| SCHEMBL2064731 | 0.70 | PDE10A (0.40) | SMN1; SMN2 | |
| SCHEMBL2064732 | 0.70 | PDE10A (0.40) | SMN1; SMN2 | |
| SCHEMBL1135255 | 0.67 | — | — | |
| SCHEMBL28792059 | 0.67 | ACKR3 (0.42) | ACKR3 | |
| SCHEMBL1752674 | 0.65 | NPC1 (0.65) | — | |
| SCHEMBL15586684 | 0.65 | NPC1 (0.65) | — | |
| SCHEMBL16420775 | 0.61 | ATR (0.67) | SMN1; SMN2 | |
| SCHEMBL16489062 | 0.61 | ATR (0.64) | SCN2ASCN10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285810-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | Abbott Laboratories (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009137308-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-11-12 | — | — | WO | disclosed |