Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 4/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376888 | 0.88 | TRPM8 (0.46) | — | |
| SCHEMBL4375164 | 0.86 | SCN2A (0.40) | SCN2ASCN10ASMN1; SMN2 | |
| SCHEMBL1134481 | 0.75 | SCN2A (0.64) | SCN2ASCN10AF2PLGPLAU | |
| SCHEMBL2064506 | 0.72 | SCN2A (0.47) | SCN2ASCN10A | |
| SCHEMBL2064507 | 0.72 | SCN2A (0.47) | SCN2ASCN10A | |
| SCHEMBL1135585 | 0.70 | SCN2A (0.52) | SCN2ASCN10A | |
| SCHEMBL5894005 | 0.65 | CA2 (0.52) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL19101078 | 0.64 | SCN2A (0.67) | SCN2ASCN10ASMN1; SMN2GRM4 | |
| SCHEMBL1135637 | 0.64 | CHRNB4 (0.56) | — | |
| SCHEMBL24775068 | 0.63 | HTR2A (0.40) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285810-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | Abbott Laboratories (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009137308-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-11-12 | — | — | WO | disclosed |