Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 10/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379009 | 0.96 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2L3MBTL1LMNANPSR1 | |
| SCHEMBL4370599 | 0.89 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL4375404 | 0.78 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL4379011 | 0.73 | LMNA (0.40) | ALDH1A1SMN1; SMN2L3MBTL1LMNANPSR1 | |
| SCHEMBL2990146 | 0.72 | PDE4A (0.46) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL1827890 | 0.72 | PDE4A (0.46) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL4366814 | 0.71 | APP (0.39) | SMN1; SMN2HPGDMEN1POLBKMT2A | |
| SCHEMBL4371697 | 0.70 | MEN1 (0.43) | SMN1; SMN2HPGDMEN1POLBKMT2A | |
| SCHEMBL682779 | 0.69 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B | |
| SCHEMBL4818551 | 0.68 | PPARG (0.51) | ALDH1A1SMN1; SMN2L3MBTL1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-B1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2014-06-04 | — | — | EP | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |