Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL9863744 | 0.98 | TDP1 (0.40) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL11002055 | 0.98 | TDP1 (0.40) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL10947437 | 0.87 | HRH4 (0.41) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL9753206 | 0.87 | HRH4 (0.44) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL1668636 | 0.87 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL289072 | 0.87 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL27340939 | 0.87 | — | — | |
| Histamine SCHEMBL7444650 | 0.87 | HRH4 (0.42) | HRH4HRH3TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL5447892 | 0.87 | — | — | |
| Histamine SCHEMBL2279 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 460 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814136-A | Imino ether compound, polyester resin composition, method for producing carboxylic acid ester, polyester film, back sheet for solar cell modules, and solar cell module | 富士胶片株式会社 | 2016-07-27 | — | — | CN | claimed |
| CN-101048432-B | Process for preparing crosslinkable oligomers | NUPLEX RESINS BV | 2013-09-11 | — | — | CN | claimed |
| CN-103193648-A | Method for preparing 2-(4-phenoxy phenyl) lactate | HANGZHOU UDRAGON CHEMICAL CO LTD | 2013-07-10 | — | — | CN | claimed |
| CN-103059204-A | Method for producing crosslinkable oligomers | NUPLEX RESINS BV | 2013-04-24 | — | — | CN | claimed |
| CN-101104617-B | Dihydropyrimidine compounds and use of the same in preparing medicament for curing and preventing virosis | BEIJING MOLIK SCIENCE & TECHNOLOGY CO LTD | 2010-06-23 | — | — | CN | claimed |
| CN-1662566-B | Process for producing fluoropolymers having a reduced amount of polar end groups | 3M INNOVATION CO LTD | 2010-06-16 | — | — | CN | claimed |
| CN-101490769-A | Insulated wire and wire harness | AUTONETWORKS TECHNOLOGIES LTD (JP) | 2009-07-22 | — | — | CN | claimed |
| CN-101365753-A | Polyamide blend compositions | GEN ELECTRIC (US) | 2009-02-11 | — | — | CN | claimed |
| CN-101365754-A | Article formed by polyamide blend compositions and method thereof | GEN ELECTRIC (US) | 2009-02-11 | — | — | CN | claimed |
| CN-100425595-C | 2-substituted pyrimidines | BASF AG (DE) | 2008-10-15 | — | — | CN | claimed |
| CN-1094928-C | 1-arylpyrazole derivatives, process for their preparation and their use | RHONE POULENC AGROCHIMIE (FR) | 2002-11-27 | — | — | CN | claimed |
| CN-1340049-A | 4- (heterocyclylsulfonylamino) -5-methoxy-6- (2-methoxyphenoxy) -2-phenyl-or-pyridylpyrimidines as endothelin receptor antagonists | HOFFMANN LA ROCHE (CH) | 2002-03-13 | — | — | CN | claimed |
| CN-1305471-A | Dihydropyrimidines | BAYER AG (DE) | 2001-07-25 | — | — | CN | claimed |
| CN-1282732-A | 'alpha'-hydroxy-'beta' amino acid ester and its preparation method | HOFFMANN LA KOCHE & CO AG F (CH) | 2001-02-07 | — | — | CN | claimed |
| CN-1053911-C | Closed-large ring lactone and closed-azalactone group new compounds and preparation process thereof | PLIVA PHARM & CHEM WORKS (HR) | 2000-06-28 | — | — | CN | claimed |
| CN-1245492-A | Pesticidal 1-arylpyrazoles | RHONE POULENC AGROCHIMIE (FR) | 2000-02-23 | — | — | CN | claimed |
| CN-1159185-A | Method for producing beta-amino alcohol | HOFFMANN LA ROCHE (CH) | 1997-09-10 | — | — | CN | claimed |
| EP-0456069-B1 | Cyclohexenonoximethers, process and intermediates for their production and their usage as herbicides | BASF AG (DE) | 1996-10-23 | — | — | EP | claimed |
| CN-1133294-A | Closed-large ring lactone and closed-azalactone group new compounds and preparation process thereof | PLIVA PHARM & CHEM WORKS (HR) | 1996-10-16 | — | — | CN | claimed |
| CN-1099387-A | Process for the preparation of beta-aminoalcohols | HOFFMANN LA ROCHE (CH) | 1995-03-01 | — | — | CN | claimed |