Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL11002055 | 1.00 | TDP1 (0.40) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL437541 | 0.98 | HRH4 (0.38) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL58710 | 0.87 | TDP1 (0.44) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL584026 | 0.87 | TDP1 (0.44) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL887606 | 0.87 | — | — | |
| Histamine SCHEMBL10947437 | 0.85 | HRH4 (0.41) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL9753206 | 0.85 | HRH4 (0.44) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL28347218 | 0.85 | TDP1 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL289072 | 0.85 | HRH4 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL7444650 | 0.85 | HRH4 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55083727-A | — | — | None | — | — | JP | disclosed |
| CN-107141234-B | A kind of azo-bis-iso-dimethyl synthetic method | 邢保林 | 2019-06-21 | — | — | CN | disclosed |
| CN-107141234-A | A kind of azo-bis-iso-dimethyl synthetic method | 邢保林 | 2017-09-08 | — | — | CN | disclosed |
| CN-101309984-B | Ink composition, manufacturing method of ink, ink set, and recording method | FUJI PHOTO FILM CO LTD | 2012-03-28 | — | — | CN | disclosed |
| CN-1997715-B | Black ink composition, ink set containing the same, and ink jet recording method | FUJI PHOTO FILM CO LTD | 2011-01-05 | — | — | CN | disclosed |
| CN-101309984-A | Ink composition, manufacturing method of ink, ink set, and recording method | FUJIFILM CORP (JP) | 2008-11-19 | — | — | CN | disclosed |
| CN-1997715-A | Black ink composition, ink set containing the same, and ink jet recording method | FUJI PHOTO FILM CO LTD (JP) | 2007-07-11 | — | — | CN | disclosed |
| CN-1134148-A | Antithrombotic amidinophenylalanine and amidinopyridylalanine derivs | PFIZER RES & DEV (IE) | 1996-10-23 | — | — | CN | disclosed |
| US-5047548-A | 3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyramide and derivatives as antifungal agents | PFIZER INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0193191-B1 | PYRIMIDINE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING SAME | Chisso Corporation (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0123907-B1 | FLUOROPYRIMIDINE DERIVATIVES | Chisso Corporation (JP) | 1989-07-26 | — | — | EP | disclosed |
| US-4684476-A | LOW VOLTAGE | CHISSO CORPORATION (JP) | 1987-08-04 | — | — | US | disclosed |
| EP-0193191-A2 | Pyrimidine derivative and liquid crystal composition containing same | Chisso Corporation (JP) | 1986-09-03 | — | — | EP | disclosed |
| US-4581155-A | LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1986-04-08 | — | — | US | disclosed |
| US-4503063-A | PLANTS AND ANIMALS | PFIZER INC. (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0123907-A2 | Fluoropyrimidine derivatives | Chisso Corporation (JP) | 1984-11-07 | — | — | EP | disclosed |
| JP-S5583727-A | PURIFICATION OF ORTHO ESTER | NIPPON SYNTHETIC CHEM IND CO LTD:THE | 1980-06-24 | — | — | JP | disclosed |
| US-3962242-A | BACTERIOSTATS, URINARY TRACT INFECTIONS | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-06-08 | — | — | US | disclosed |