Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135845 | 0.86 | ADRA2A (0.54) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL1019102 | 0.85 | MAPT (0.55) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL3064038 | 0.83 | ALDH1A1 (0.54) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL8163779 | 0.80 | MAPT (0.50) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL20819271 | 0.79 | ALOX5 (0.52) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL30300872 | 0.78 | MAPT (0.48) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL27477064 | 0.78 | ALOX5 (0.59) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL12330711 | 0.78 | ADRA2A (0.46) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL15807639 | 0.78 | PTPN11 (0.62) | MAPTRAB9AALOX5NPC1SMN1; SMN2 | |
| SCHEMBL18059295 | 0.77 | ALOX5 (0.53) | MAPTRAB9AALOX5NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114158-A1 | 3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008085505-A1 | 3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |