Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.44 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.36 |
| ▸ | PPARG | P37231 | 8/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379890 | 0.91 | AKT1 (0.43) | AKT1AKT2AKT3EPHX2PPARG | |
| SCHEMBL4380618 | 0.85 | ALDH1A1 (0.41) | AKT1AKT2AKT3EPHX2PPARG | |
| SCHEMBL27770723 | 0.82 | AKT1 (0.46) | AKT1AKT2AKT3KIFC1EPHX2 | |
| SCHEMBL3506057 | 0.80 | AKT1 (0.49) | AKT1AKT2AKT3KIFC1EPHX2 | |
| SCHEMBL3506060 | 0.80 | AKT1 (0.49) | AKT1AKT2AKT3KIFC1EPHX2 | |
| SCHEMBL4382045 | 0.80 | EPHX2 (0.37) | AKT1AKT2AKT3EPHX2PPARG | |
| SCHEMBL4543991 | 0.80 | AKT1 (0.45) | AKT1AKT2AKT3EPHX2 | |
| SCHEMBL12679845 | 0.79 | AKT1 (0.50) | AKT1AKT2AKT3KIFC1EPHX2 | |
| SCHEMBL1529857 | 0.79 | AKT1 (0.46) | AKT1AKT2AKT3KIFC1EPHX2 | |
| SCHEMBL1529859 | 0.79 | AKT1 (0.46) | AKT1AKT2AKT3KIFC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |