SCHEMBL437631

SCHEMBL437631

c1ccc(-c2ccc3oc4c(-c5cccc(C6(c7cccc(-c8cc(-c9ccccc9)cc9c8oc8ccc(-c%10ccccc%10)cc89)c7)c7ccccc7-c7ccccc76)c5)cc(-c5ccccc5)cc4c3c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.37
PIM1 P11309 1/20 0.36
CSNK2A2 P19784 1/20 0.36
CSNK2B P67870 1/20 0.36
PIM3 Q86V86 1/20 0.36
PIM2 Q9P1W9 1/20 0.36
PLA2G2A P14555 4/20 0.35
PLA2G4A P47712 4/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
PLA2G10 O15496 1/20 0.33
PDK2 Q15119 1/20 0.33
PRKDC P78527 4/20 0.32
GGPS1 O95749 1/20 0.31
MEN1 O00255 2/20 0.31
LMNA P02545 2/20 0.31
MAPT P10636 2/20 0.31
KMT2A Q03164 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL438611 0.99 ALOX5 (0.36) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL440624 0.98 ALOX5 (0.36) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL440619 0.92 MEN1 (0.35) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL438792 0.92 ALOX5 (0.36) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL438756 0.92 MEN1 (0.37) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL440606 0.90 MEN1 (0.38) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL440628 0.88 CHRNA1 (0.39) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL440063 0.88 ESR1 (0.38) PIM1CSNK2A2CSNK2BPIM3ESR1
SCHEMBL440621 0.87 MEN1 (0.37) ALOX5PIM1CSNK2A2CSNK2BPIM3
SCHEMBL20706772 0.86 PLA2G2A (0.35) ALOX5PIM1CSNK2A2CSNK2BPIM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9564597-B2 Fluorene compound, light-emitting element, light-emitting device, electronic device, lighting device, and organic compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-02-07 US disclosed
US-9564597-B2 Fluorene compound, light-emitting element, light-emitting device, electronic device, lighting device, and organic compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2017-02-07 US disclosed
US-20150243899-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-08-27 US disclosed
US-20150243899-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-08-27 US disclosed
US-8993127-B2 Fluorene compound, light-emitting element, light-emitting device, electronic device, lighting device, and organic compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-31 US disclosed
US-8993127-B2 Fluorene compound, light-emitting element, light-emitting device, electronic device, lighting device, and organic compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-31 US disclosed
EP-2428512-B1 Fluorene compound, light-emitting element, light-emitting device, electronic device and lighting device SEMICONDUCTOR ENERGY LAB (JP) 2014-10-22 EP disclosed
US-20120061714-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-15 US disclosed
US-20120061714-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150243899-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound CYP1A1, CYP1B1, DRD1 ALOX5 1299/4885PIM1 4448/4885CSNK2A2 1539/4885
US-20120061714-A1 Fluorene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Organic Compound CYP1A1, CYP1B1, DRD1 ALOX5 1299/4885PIM1 4448/4885CSNK2A2 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.