SCHEMBL4376931

SCHEMBL4376931

O=C1c2c(Br)c(Br)c(Br)c(Br)c2C(=O)N1c1ccc(Oc2ccc(N3C(=O)c4c(Br)c(Br)c(Br)c(Br)c4C3=O)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA9 Q16790 6/20 0.57
CA2 P00918 5/20 0.57
CA12 O43570 4/20 0.57
CA7 P43166 4/20 0.57
CA1 P00915 3/20 0.57
MGLL Q99685 2/20 0.46
LMNA P02545 2/20 0.41
ALDH1A1 P00352 1/20 0.41
NR1H3 Q13133 1/20 0.40
BRD4 O60885 1/20 0.40
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
HIPK2 Q9H2X6 1/20 0.39
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
PTGES O14684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3676125 0.88 CA9 (0.69) CA9CA2CA12CA7CA1
SCHEMBL18098168 0.84 CA9 (0.47) CA9CA2CA12CA7CA1
SCHEMBL18098043 0.81 CA9 (0.42) CA9CA2CA12CA7CA1
SCHEMBL12172936 0.78 CA9 (0.60) CA9CA2CA12CA7CA1
SCHEMBL10937683 0.78 CA9 (0.59) CA9CA2CA12CA7CA1
SCHEMBL3682338 0.78 CA9 (0.58) CA9CA2CA12CA7CA1
SCHEMBL13258837 0.77 MGLL (0.46) CA9CA2CA12CA7CA1
SCHEMBL4368968 0.77 NR1H3 (0.62) CA9CA2CA12CA7CA1
SCHEMBL4365102 0.77 CA9 (0.57) CA9CA2CA12CA7CA1
SCHEMBL21985848 0.76 CA9 (0.57) CA9CA2CA12CA7CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090308001-A1 Substrate and the application Wu, Shaobing (US) 2009-12-17 US disclosed
US-20040072929-A1 Flame retardant compositions DE SCHRYVER DANIEL A (BE) 2004-04-15 US disclosed
EP-1405879-A1 FLAME RETARDANT POLYETHYLENE TEREPHTHALATE RESIN COMPOSITION Win Tech Polymer Ltd. (JP) 2004-04-07 EP disclosed
WO-2004003071-A1 FLAME RETARDANT COMPOSITIONS ALBEMARLE CORPORATION (US) 2004-01-08 WO disclosed
EP-0604078-B1 Glass filled flame retardant polyester compositions with improved color GEN ELECTRIC (US) 1997-04-23 EP disclosed
US-5371123-A Polyepoxide or polyolefin coating agent GENERAL ELECTRIC COMPANY (US) 1994-12-06 US disclosed
EP-0604078-A1 Glass filled flame retardant polyester compositions with improved color GENERAL ELECTRIC COMPANY (US) 1994-06-29 EP disclosed
US-5043371-A Blend with halogenated bisimide, polytetrafluoroethylene and low molecular weigth polyethylene POLYPLASTICS CO., LTD. (JP) 1991-08-27 US disclosed
EP-0400936-A1 Flame-retardant polyester resin compositions POLYPLASTICS CO. LTD. (JP) 1990-12-05 EP disclosed