SCHEMBL4368968

SCHEMBL4368968

O=C1c2c(Cl)c(Cl)c(Cl)c(Cl)c2C(=O)N1c1ccc(Oc2ccc(N3C(=O)c4c(Cl)c(Cl)c(Cl)c(Cl)c4C3=O)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NR1H3 Q13133 7/20 0.62
CA9 Q16790 3/20 0.59
CA1 P00915 3/20 0.59
CA12 O43570 2/20 0.59
CA2 P00918 2/20 0.59
CA7 P43166 2/20 0.59
NR1H2 P55055 2/20 0.53
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
MGLL Q99685 1/20 0.46
DPP8 Q6V1X1 1/20 0.44
KDM4E B2RXH2 1/20 0.44
HPGD P15428 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1811288 0.88 CA9 (0.71) NR1H3CA9CA1CA12CA2
SCHEMBL1816383 0.82 CA9 (0.65) NR1H3CA9CA1CA12CA2
SCHEMBL10976600 0.82 CA9 (0.65) NR1H3CA9CA1CA12CA2
SCHEMBL16425603 0.78 CA9 (0.61) NR1H3CA9CA1CA12CA2
SCHEMBL3680527 0.78 DPP8 (0.65) NR1H3CA9CA1CA12CA2
SCHEMBL9438287 0.77 CA2 (0.74) NR1H3CA9CA1CA12CA2
SCHEMBL4376929 0.77 NR1H3 (0.62) NR1H3CA9CA1CA12CA2
SCHEMBL4376931 0.77 CA9 (0.57) NR1H3CA9CA1CA12CA2
SCHEMBL13258837 0.77 MGLL (0.46) NR1H3CA9CA1CA12CA2
SCHEMBL17187939 0.76 HPGD (0.56) NR1H3ALDH1A1LMNAMGLLKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090308001-A1 Substrate and the application Wu, Shaobing (US) 2009-12-17 US disclosed
US-20040072929-A1 Flame retardant compositions DE SCHRYVER DANIEL A (BE) 2004-04-15 US disclosed
EP-0604078-B1 Glass filled flame retardant polyester compositions with improved color GEN ELECTRIC (US) 1997-04-23 EP disclosed
US-5371123-A Polyepoxide or polyolefin coating agent GENERAL ELECTRIC COMPANY (US) 1994-12-06 US disclosed
EP-0604078-A1 Glass filled flame retardant polyester compositions with improved color GENERAL ELECTRIC COMPANY (US) 1994-06-29 EP disclosed
US-5043371-A Blend with halogenated bisimide, polytetrafluoroethylene and low molecular weigth polyethylene POLYPLASTICS CO., LTD. (JP) 1991-08-27 US disclosed
EP-0400936-A1 Flame-retardant polyester resin compositions POLYPLASTICS CO. LTD. (JP) 1990-12-05 EP disclosed