Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908350 | 0.93 | HSD11B1 (0.46) | HSD11B1OPRL1POLBTACR1NPY1R | |
| SCHEMBL378786 | 0.90 | MEN1 (0.46) | HSD11B1OPRL1POLBCCR1KMT2A | |
| SCHEMBL7908251 | 0.85 | MAPT (0.42) | HSD11B1POLBCCR1KMT2AMEN1 | |
| SCHEMBL3721822 | 0.83 | ADRB3 (0.40) | HSD11B1OPRL1TACR1SLC6A4PTPN1 | |
| SCHEMBL7910338 | 0.83 | TACR1 (0.47) | HSD11B1OPRL1TACR1KMT2AMEN1 | |
| SCHEMBL378790 | 0.83 | TACR1 (0.47) | HSD11B1OPRL1TACR1KMT2AMEN1 | |
| SCHEMBL379032 | 0.83 | ADRB3 (0.39) | HSD11B1OPRL1TACR1SLC6A4PTPN1 | |
| SCHEMBL378802 | 0.82 | SLC6A9 (0.47) | HSD11B1TACR1KMT2AMEN1SLC6A7 | |
| SCHEMBL3714839 | 0.79 | NPC1 (0.49) | HSD11B1POLBTACR1NPY1RSLC6A4 | |
| SCHEMBL7908348 | 0.79 | HSD11B1 (0.48) | HSD11B1OPRL1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408745-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-25 | — | — | EP | disclosed |