Sugi Predict

Sugi Predict / Compounds / SCHEMBL43771

SCHEMBL43771

SCHEMBL43771

O=C(O)c1cc(C(F)(F)F)ccc1F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.59
▸ HPGD P15428 3/20 0.59
▸ KDM4E B2RXH2 2/20 0.59
▸ HSD17B10 Q99714 2/20 0.59
▸ MRGPRX4 Q96LA9 1/20 0.56
▸ CES2 O00748 2/20 0.53
▸ USP2 O75604 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ LIPG Q9Y5X9 2/20 0.49
▸ LIPC P11150 1/20 0.49
▸ MEN1 O00255 1/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ ALOX5AP P20292 1/20 0.47
▸ FEN1 P39748 1/20 0.47
▸ SORT1 Q99523 2/20 0.47
▸ KDM1A O60341 1/20 0.47
▸ ACLY P53396 1/20 0.46
▸ SRD5A2 P31213 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382489 1.00 ALDH1A1 (0.59) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL20638868 0.85 MRGPRX4 (0.44) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL283914 0.84 KDM4E (0.65) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL460066 0.83 KDM4E (0.69) ALDH1A1HPGDKDM4EHSD17B10CES2
SCHEMBL2073688 0.82 CES2 (0.52) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL29786688 0.82 CES2 (0.52) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
Hydrochloric Acid SCHEMBL6498102 0.82 KDM4E (0.62) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL8813550 0.82 CES2 (0.56) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL283293 0.82 CES2 (0.52) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4
SCHEMBL1326879 0.82 CES2 (0.52) ALDH1A1HPGDKDM4EHSD17B10MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 532 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 — — CN claimed
EP-3551633-B1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA AS (DK) 2021-03-31 — — EP claimed
CN-107681052-B Main group metal complexes as p-dopants for organic electronic matrix materials 西门子公司 2020-03-24 — — CN claimed
US-10483466-B2 P-doping cross-linking of organic hole transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2019-11-19 — — US claimed
EP-3114715-B1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS SIEMENS AG (DE) 2019-10-30 — — EP claimed
EP-3551633-A1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Leo Pharma A/S (DK) 2019-10-16 — — EP claimed
CN-110088108-A SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS 利奥制药有限公司 2019-08-02 — — CN claimed
US-20180198069-A1 P-Doping Cross-Linking Of Organic Hole Transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2018-07-12 — — US claimed
WO-2018108230-A1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2018-06-21 — — WO claimed
EP-3057151-B1 BISMUTH AND TIN COMPLEXES AS P DOTANDS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SIEMENS AG (DE) 2018-01-31 — — EP claimed
US-20170098787-A1 MAIN GROUP METAL COMPLEXES AS P-DOPANTS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SIEMENS AKTIENGESELLSCHAFT (DE) 2017-04-06 — — US claimed
EP-3057151-A1 PRINCIPAL GROUP METAL COMPLEXES AS P DOTANDS FOR ORGANIC ELECTRONIC MATRIX MATERIALS Siemens Aktiengesellschaft (DE) 2016-08-17 — — EP claimed
CN-102056883-B Process for the preparation of halogenated benzoic acid derivatives HOFFMANN LA ROCHE 2014-11-12 — — CN claimed
US-8853619-B2 Method for detecting tracer compounds for hydrocarbon production TOTAL S.A. (FR) 2014-10-07 — — US claimed
US-20110260051-A1 METHOD FOR DETECTING TRACER COMPOUNDS FOR HYDROCARBON PRODUCTION TOTAL S.A. (FR) 2011-10-27 — — US claimed
WO-2005075471-A2 THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS BIOVITRUM AB (SE) 2005-08-18 — — WO claimed
EP-4274572-B1 NOVEL INHIBITORS OF AUTOTAXIN ZYDUS LIFESCIENCES LTD (IN) 2026-02-18 — — EP disclosed
US-20250368647-A1 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2025-12-04 — — US disclosed
US-4810795-A ANTIHISTAMINES A. H. ROBINS COMPANY, INCORPORATED (US) 1989-03-07 — — US disclosed
US-4705853-A ANTIHISTAMINES A. H. ROBINS COMPANY, INC. (US) 1987-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170098787-A1 MAIN GROUP METAL COMPLEXES AS P-DOPANTS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SCO2, SOD3, NCOA3 ALDH1A1 1949/4885HPGD 2201/4885KDM4E 1107/4885
US-20250368647-A1 NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS SCN8A, SCN2A, SCN5A ALDH1A1 2933/4885HPGD 549/4885KDM4E 2636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.