⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391797 | 0.88 | GABRA1 (0.32) | — | |
| SCHEMBL4380953 | 0.86 | HRH3 (0.35) | — | |
| SCHEMBL4383603 | 0.79 | ADRA1A (0.42) | — | |
| SCHEMBL4386727 | 0.78 | PPARG (0.32) | — | |
| SCHEMBL4377932 | 0.77 | KCNH2 (0.40) | — | |
| SCHEMBL4383597 | 0.76 | ADRA1A (0.42) | — | |
| SCHEMBL4390054 | 0.71 | L3MBTL1 (0.39) | — | |
| SCHEMBL8795928 | 0.69 | ADRA1A (0.41) | — | |
| SCHEMBL5322896 | 0.68 | HRH4 (0.32) | — | |
| SCHEMBL8793556 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |