Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 7/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377924 | 0.83 | AKT1 (0.38) | AKT1MAPK1TACR3 | |
| SCHEMBL4541583 | 0.79 | ITGB1 (0.38) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL4540065 | 0.79 | AKT1 (0.45) | AKT1MAPK1 | |
| SCHEMBL1529867 | 0.79 | MMP12 (0.44) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL1529865 | 0.79 | MMP12 (0.44) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL1529505 | 0.77 | AKT1 (0.49) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL4543985 | 0.76 | AKT1 (0.47) | AKT1MAPK1 | |
| SCHEMBL1529645 | 0.73 | AKT1 (0.43) | MMP12MMP13AKT1MAPK1 | |
| SCHEMBL27770734 | 0.72 | DAO (0.45) | AKT1LDHA | |
| SCHEMBL4554171 | 0.71 | DHPS (0.42) | AKT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |