Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.45 |
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | PRKACB | P22694 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 6/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541583 | 0.91 | ITGB1 (0.38) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4375486 | 0.83 | MAPK1 (0.36) | AKT1MAPK1 | |
| SCHEMBL1529417 | 0.83 | AKT1 (0.59) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL1529885 | 0.80 | AKT1 (0.46) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4552985 | 0.79 | AKT1 (0.43) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4378235 | 0.79 | MMP12 (0.40) | AKT1MAPK1 | |
| SCHEMBL12679242 | 0.78 | AKT1 (0.45) | AKT1AKT2AKT3ROCK2PRKCB | |
| SCHEMBL4374524 | 0.78 | ALDH1A1 (0.47) | — | |
| SCHEMBL4583485 | 0.78 | ALDH1A1 (0.47) | — | |
| SCHEMBL4544057 | 0.76 | ULK1 (0.39) | AKT1MAPK1ITGA4ITGB7ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |