Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.56 |
| ▸ | CCND1 | P24385 | 4/20 | 0.56 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | PELI1 | Q96FA3 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478041 | 0.85 | CDK4 (0.53) | CDK4CCND1BACE1ALDH1A1CCNB2 | |
| SCHEMBL9421131 | 0.85 | CDK4 (0.53) | CDK4CCND1BACE1ALDH1A1CCNB2 | |
| SCHEMBL9421139 | 0.85 | CDK4 (0.53) | CDK4CCND1BACE1ALDH1A1CCNB2 | |
| SCHEMBL9244314 | 0.83 | ALDH1A1 (0.48) | CDK4CCND1BACE1ALDH1A1CCNB2 | |
| SCHEMBL9244312 | 0.83 | ALDH1A1 (0.48) | CDK4CCND1BACE1ALDH1A1CCNB2 | |
| SCHEMBL5725728 | 0.82 | CDK4 (0.47) | CDK4CCND1ALDH1A1CCNB2CDK1 | |
| SCHEMBL7935139 | 0.82 | CDK4 (0.47) | CDK4CCND1BACE1ALDH1A1MAPT | |
| SCHEMBL8921603 | 0.82 | CDK4 (0.47) | CDK4CCND1ALDH1A1MAPTCCNB2 | |
| SCHEMBL7935137 | 0.82 | CDK4 (0.47) | CDK4CCND1BACE1ALDH1A1MAPT | |
| SCHEMBL5013561 | 0.81 | XDH (0.51) | BACE1ABL1ABCB1BCRESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |