SCHEMBL8921603

SCHEMBL8921603

O=C/C=C/c1ccccc1-c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 3/20 0.47
CCND1 P24385 3/20 0.47
PTGS2 P35354 2/20 0.42
PTGS1 P23219 1/20 0.42
PTGER1 P34995 1/20 0.42
PTGER3 P43115 1/20 0.42
PTGER2 P43116 1/20 0.42
MAPK1 P28482 2/20 0.39
LMNA P02545 2/20 0.39
ALDH1A1 P00352 2/20 0.39
TRPA1 O75762 1/20 0.39
ALOX5 P09917 1/20 0.39
CCNB2 O95067 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39
CCNB3 Q8WWL7 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9421139 0.85 CDK4 (0.53) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL9421131 0.85 CDK4 (0.53) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL1478041 0.85 CDK4 (0.53) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL9244314 0.83 ALDH1A1 (0.48) CDK4CCND1PTGS2PTGER1PTGER3
SCHEMBL9244312 0.83 ALDH1A1 (0.48) CDK4CCND1PTGS2PTGER1PTGER3
SCHEMBL5725728 0.82 CDK4 (0.47) CDK4CCND1PTGS2PTGS1PTGER1
SCHEMBL7935137 0.82 CDK4 (0.47) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL7935139 0.82 CDK4 (0.47) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL4378587 0.82 CDK4 (0.56) CDK4CCND1PTGER1PTGER3PTGER2
SCHEMBL387189 0.81 XDH (0.51) PTGS2PTGS1PTGER1PTGER3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0802897-A1 NOVEL COMPOUNDS Smithkline Beecham S.p.A. (IT) 1997-10-29 EP disclosed
WO-1996021638-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM S.P.A. (IT) 1996-07-18 WO disclosed
EP-0613890-A1 Novel triazole compound, process for preparing the same and antifungal agent containing the same NIHON NOHYAKU CO., LTD. (JP) 1994-09-07 EP disclosed
US-4804785-A INTERMEDIATES FOR HYDROXYMETHYLOXIRANES BASF AKTIENGESELLSCHAFT (DE) 1989-02-14 US disclosed
US-4723042-A REARRANGEMENT OF AN OXYKETONE USING A PHOSPHORUS COMPOUND BASF AKTIENGESELLSCHAFT (DE) 1988-02-02 US disclosed