Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380083 | 0.87 | TLR8 (0.37) | PTPN1 | |
| SCHEMBL3739137 | 0.84 | HSD17B10 (0.38) | PTPN1HSD17B10DPP4DPP8 | |
| SCHEMBL4375859 | 0.83 | PTPN1 (0.42) | PTPN1 | |
| SCHEMBL4374199 | 0.74 | TLR8 (0.44) | PTPN1 | |
| SCHEMBL4380078 | 0.74 | CHRNB2 (0.33) | PTPN1 | |
| SCHEMBL3734163 | 0.70 | PTPN1 (0.37) | PTPN1HSD17B10 | |
| SCHEMBL3727477 | 0.69 | PTPN1 (0.38) | PTPN1DPP4DPP8 | |
| SCHEMBL3742651 | 0.69 | TLR8 (0.39) | — | |
| SCHEMBL3729445 | 0.68 | HSP90AA1 (0.41) | PTPN1HSD17B10 | |
| SCHEMBL4531694 | 0.68 | BACE1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |