Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375859 | 0.91 | PTPN1 (0.42) | TLR8PTPN1CTSKHSD11B1KMO | |
| SCHEMBL3734730 | 0.85 | PTPN1 (0.41) | TLR8PTPN1HSD11B1KMOTRPA1 | |
| SCHEMBL4371511 | 0.77 | PTPN1 (0.43) | PTPN1TRPA1SCN9A | |
| SCHEMBL4380083 | 0.75 | TLR8 (0.37) | TLR8PTPN1BACE1ATR | |
| SCHEMBL4378608 | 0.74 | PTPN1 (0.36) | PTPN1 | |
| SCHEMBL3742273 | 0.74 | PTPN1 (0.36) | TLR8PTPN1 | |
| SCHEMBL3732086 | 0.74 | PTPN1 (0.42) | TLR8PTPN1HSD11B1TRPA1BACE1 | |
| SCHEMBL3730117 | 0.72 | TRPV3 (0.37) | SCN9ACYP1A2 | |
| SCHEMBL4384328 | 0.71 | PTPN1 (0.36) | TLR8PTPN1CTSK | |
| SCHEMBL3732360 | 0.70 | PTPN1 (0.45) | PTPN1HSD11B1TRPA1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |