Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378608 | 0.87 | PTPN1 (0.36) | PTPN1 | |
| SCHEMBL4375859 | 0.84 | PTPN1 (0.42) | TLR8PTPN1BACE1ATR | |
| SCHEMBL3734163 | 0.84 | PTPN1 (0.37) | TLR8PTPN1GRM2BACE1CTSD | |
| SCHEMBL4531694 | 0.78 | BACE1 (0.39) | TLR8BACE1CTSDADORA1 | |
| SCHEMBL4374199 | 0.75 | TLR8 (0.44) | TLR8PTPN1BACE1ATR | |
| SCHEMBL4380078 | 0.74 | CHRNB2 (0.33) | PTPN1 | |
| SCHEMBL4531703 | 0.69 | BACE1 (0.37) | TLR8BACE1CTSDADORA1 | |
| SCHEMBL3729445 | 0.68 | HSP90AA1 (0.41) | TLR8PTPN1GRM2ATRADORA2A | |
| SCHEMBL3734730 | 0.68 | PTPN1 (0.41) | TLR8PTPN1BACE1ATR | |
| SCHEMBL4534826 | 0.67 | HTR7 (0.41) | BACE1CTSDADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910359-B1 | PYRIDO [2 , 3-D]PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | claimed |