SCHEMBL43788

SCHEMBL43788

C#Cc1ccc(COC(C)=O)cc1

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
CYP3A4 P08684 1/20 0.46
GRIN2B Q13224 1/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CA2 P00918 1/20 0.38
ACACB O00763 1/20 0.37
TSHR P16473 1/20 0.37
MAOB P27338 1/20 0.37
POLB P06746 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
IDH1 O75874 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL132773 0.84 ALDH1A1 (0.78) ALDH1A1CYP3A4MEN1KMT2ACA2
SCHEMBL24802638 0.82 FFAR1 (0.40) ALDH1A1ACACBTSHR
SCHEMBL18641307 0.81 GRIN2B (0.41) ALDH1A1GRIN2BMEN1KMT2ACA2
SCHEMBL17283451 0.81 ALDH1A1 (0.58) ALDH1A1GRIN2BMEN1KMT2APOLB
SCHEMBL2659564 0.81 ALDH1A1 (0.58) ALDH1A1CYP3A4TSHRMAOBTDP1
SCHEMBL30275198 0.81 TOP2A (0.49) ALDH1A1GRIN2BMEN1KMT2A
SCHEMBL19628650 0.80 ALDH1A1 (0.51) ALDH1A1CYP3A4CA2MAOBPOLB
SCHEMBL4773202 0.80 ALDH1A1 (0.56) ALDH1A1CYP3A4CA2MAOBIDH1
SCHEMBL11315920 0.78 ALDH1A1 (0.69) ALDH1A1CYP3A4MEN1KMT2ACA2
SCHEMBL10604973 0.78 ALDH1A1 (0.69) ALDH1A1CYP3A4MEN1KMT2ACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011157444-A1 FUNCTIONALIZED MATERIALS BY CATALYZED CARBENE COPOLYMERIZATION STICHTING DUTCH POLYMER INSTITUTE (NL) 2011-12-22 WO disclosed