Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AOC1 | P19801 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651691 | 0.85 | CYP4F2 (0.50) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL18808055 | 0.84 | ALDH1A1 (0.54) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL27582108 | 0.83 | CCNC (0.55) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL27224524 | 0.83 | CCNC (0.55) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL8216031 | 0.82 | AOC1 (0.52) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL19799358 | 0.81 | CCNC (0.54) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL15773725 | 0.81 | CCNC (0.54) | CCNCCDK8ALDH1A1KDM4EMAPT | |
| SCHEMBL2999880 | 0.80 | AOC1 (0.53) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL19838578 | 0.77 | ALDH1A1 (0.54) | CCNCCDK8ALDH1A1KDM4EGLA | |
| SCHEMBL29792765 | 0.77 | ALDH1A1 (0.54) | CCNCCDK8ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-B1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TIANJIN HEMAY BIO TECH CO LTD (CN) | 2014-06-04 | — | — | EP | disclosed |
| CN-101186612-B | Pyrroline derivative capable of inhibiting cell to release tumor necrotic factor and its preparation and application | TIANJIN HEMEI BIOLOG TECHNOLOGY CO LTD | 2012-10-03 | — | — | CN | disclosed |
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |
| CN-101186612-A | Pyrroline derivative capable of inhibiting cell to release tumor necrotic factor and its preparation and application | TIANJIN HEMEI BIOLOG TECHNOLOG (CN) | 2008-05-28 | — | — | CN | disclosed |
| CN-1320125-A | Trizolopyridines for the treamtent of thrombosis disorders | ORTHO MCNEIL PHARM INC (US) | 2001-10-31 | — | — | CN | disclosed |