Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003208 | 0.96 | FAAH (0.53) | FAAHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL3005180 | 0.95 | JAK2 (0.42) | FAAHL3MBTL1MEN1KMT2AJAK2 | |
| SCHEMBL4377506 | 0.90 | FAAH (0.45) | FAAHL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3006234 | 0.89 | JAK2 (0.46) | FAAHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL4097912 | 0.88 | FAAH (0.51) | FAAHMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4384519 | 0.88 | FAAH (0.48) | FAAHL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4375846 | 0.88 | FAAH (0.46) | FAAHL3MBTL1MEN1KMT2AJAK2 | |
| SCHEMBL4384405 | 0.88 | FAAH (0.51) | FAAHMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4094004 | 0.87 | L3MBTL1 (0.44) | FAAHL3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2999250 | 0.87 | FAAH (0.48) | FAAHL3MBTL1MEN1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |