Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001437 | 0.96 | FAAH (0.49) | FAAHALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL2996189 | 0.95 | L3MBTL1 (0.44) | FAAHL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3007840 | 0.89 | TSHR (0.42) | FAAHALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4378987 | 0.88 | FAAH (0.49) | FAAHL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4377506 | 0.87 | FAAH (0.45) | FAAHL3MBTL1LMNASMN1; SMN2RAB9A | |
| SCHEMBL3006567 | 0.86 | FAAH (0.47) | FAAHL3MBTL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3007020 | 0.85 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL4090027 | 0.85 | FAAH (0.46) | FAAHALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL3006403 | 0.85 | FAAH (0.61) | FAAHHTTMEN1KMT2AMAPT | |
| SCHEMBL3010950 | 0.85 | LMNA (0.47) | ALDH1A1LMNASMN1; SMN2TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |