Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.62 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL8851022 | 1.00 | PTGS1 (0.62) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL12129512 | 1.00 | PTGS1 (0.62) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| 2-{3-[Hydroxy(Phenyl)Methyl]Phenyl}Propanoic Acid SCHEMBL8851028 | 1.00 | PTGS1 (0.62) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL602096 | 0.88 | PTGS2 (0.69) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL1344829 | 0.85 | PTGS1 (0.61) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL1345442 | 0.85 | PTGS1 (0.61) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL1345440 | 0.85 | PTGS1 (0.61) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL12018881 | 0.83 | PTGS1 (0.64) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL3630168 | 0.83 | PTGS1 (0.64) | PTGS1PTGS2LMNAMAPTCXCR1 | |
| SCHEMBL3147627 | 0.83 | PTGS1 (0.64) | PTGS1PTGS2LMNAMAPTCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255726-B1 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-11-11 | — | — | EP | disclosed |
| US-20040181073-A1 | Amides, useful in the inhibition of il-8-induced chemotaxis of neutrophils | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2004-09-16 | — | — | US | disclosed |
| EP-0529444-B1 | 2-Arylpropenic acids and their utilisation in the preparation of 5-ketoprofen | BAYER AG (DE) | 1997-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181073-A1 | Amides, useful in the inhibition of il-8-induced chemotaxis of neutrophils | CXCL8, MMP8, CCR8 | PTGS1 171/4885PTGS2 219/4885LMNA 3228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.