Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | CLK3 | P49761 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859116 | 0.79 | MAP2K4 (0.48) | NTRK1MAP2K4TTKFYNLRRK2 | |
| SCHEMBL2863456 | 0.78 | TTK (0.48) | NTRK1MAP2K4TTKFYNCLK2 | |
| SCHEMBL2863072 | 0.77 | TTK (0.47) | NTRK1MAP2K4TTKFYNCLK2 | |
| SCHEMBL2864633 | 0.75 | MAP2K4 (0.47) | NTRK1MAP2K4TTKFYNLRRK2 | |
| SCHEMBL4327628 | 0.75 | GSK3B (0.53) | NTRK1CLK2DYRK1AGSK3AGSK3B | |
| SCHEMBL2862698 | 0.74 | NTRK1 (0.44) | NTRK1MAP2K4TTKFYNCLK2 | |
| SCHEMBL2864166 | 0.74 | NTRK1 (0.49) | NTRK1MAP2K4TTKFYNCLK2 | |
| SCHEMBL4335949 | 0.71 | CDK9 (0.44) | NTRK1TTKCLK2CLK3DYRK1A | |
| SCHEMBL13198269 | 0.71 | MEN1 (0.41) | NTRK1MAP2K4TTKDYRK1AGSK3A | |
| SCHEMBL4335950 | 0.71 | MEN1 (0.41) | NTRK1MAP2K4TTKDYRK1AGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1380576-B1 | 1H-INDAZOLE COMPOUNDS INHIBITING JNK | EISAI R&D MAN CO LTD (JP) | 2009-11-25 | — | — | EP | disclosed |