Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384924 | 0.87 | MAPT (0.54) | MAPTPRKCQSIRT5EGFRIGF1R | |
| SCHEMBL4392529 | 0.86 | MAPT (0.48) | MAPTPRKCQSIRT5IDO1NPC1 | |
| SCHEMBL4379701 | 0.85 | MAPT (0.46) | MAPTPRKCQSIRT5NPC1ALDH1A1 | |
| SCHEMBL4387612 | 0.84 | PRKCQ (0.68) | PRKCQSIRT5MAP4K4 | |
| SCHEMBL1182286 | 0.82 | MAPT (0.56) | MAPTPRKCQSIRT5MAP4K4TXNRD1 | |
| SCHEMBL10353602 | 0.72 | MAPT (0.72) | MAPTPRKCQEGFRIGF1RRECQL | |
| SCHEMBL1182094 | 0.72 | MAPT (0.52) | MAPTSIRT5APPNPC1ALDH1A1 | |
| SCHEMBL4380044 | 0.71 | PRKCQ (0.69) | PRKCQSIRT5L3MBTL1 | |
| SCHEMBL1748266 | 0.71 | MAPT (0.51) | MAPTPRKCQEGFRIGF1RAPP | |
| SCHEMBL16586038 | 0.71 | PRKCQ (0.64) | MAPTPRKCQMAP4K4EGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066665-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008043087-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |