Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380349 | 0.87 | MAPT (0.55) | MAPTSIRT5EGFRIGF1RPRKCQ | |
| SCHEMBL906583 | 0.82 | MAPT (0.55) | MAPTSIRT5ALOX5EGFRIGF1R | |
| SCHEMBL4392529 | 0.81 | MAPT (0.48) | MAPTSIRT5PRKCQSMN1; SMN2IDO1 | |
| SCHEMBL4379701 | 0.78 | MAPT (0.46) | MAPTSIRT5PRKCQPOLBMAPK1 | |
| SCHEMBL4387612 | 0.71 | PRKCQ (0.68) | SIRT5PRKCQ | |
| SCHEMBL1182094 | 0.71 | MAPT (0.52) | MAPTSIRT5APPATG4BPOLB | |
| SCHEMBL4380044 | 0.70 | PRKCQ (0.69) | SIRT5PRKCQ | |
| SCHEMBL1182286 | 0.70 | MAPT (0.56) | MAPTSIRT5PRKCQATG4BPOLB | |
| SCHEMBL1748023 | 0.70 | HTR6 (0.50) | MAPTALOX5EGFRIGF1RAPP | |
| SCHEMBL7189543 | 0.69 | GSK3B (0.56) | MAPTSIRT5POLBSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066665-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008043087-A2 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL COA DESATURASE INHIBITORS | CV THERAPEUTICS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |