Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 13/20 | 0.47 |
| ▸ | DRD2 | P14416 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385545 | 0.96 | DRD3 (0.47) | DRD3DRD2KCNH2USP2HRH1 | |
| SCHEMBL4387400 | 0.94 | DRD3 (0.48) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4387104 | 0.90 | DRD3 (0.59) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4381736 | 0.86 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4383491 | 0.86 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4701185 | 0.83 | DRD3 (0.57) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4705240 | 0.82 | DRD3 (0.58) | DRD3DRD2KCNH2HRH1ALDH1A1 | |
| SCHEMBL4397119 | 0.81 | DRD3 (0.47) | DRD3DRD2KCNH2USP2HRH1 | |
| SCHEMBL4703079 | 0.81 | DRD3 (0.59) | DRD3DRD2KCNH2ALDH1A1TSHR | |
| SCHEMBL4704001 | 0.79 | DRD3 (0.55) | DRD3DRD2KCNH2HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | claimed |