Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 16/20 | 0.57 |
| ▸ | DRD2 | P14416 | 15/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702577 | 0.93 | ALDH1A1 (0.57) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL4861989 | 0.92 | ALDH1A1 (0.56) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| SCHEMBL4387104 | 0.91 | DRD3 (0.59) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| SCHEMBL4705240 | 0.90 | DRD3 (0.58) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| SCHEMBL4704579 | 0.88 | DRD3 (0.59) | DRD3DRD2KCNH2ALDH1A1MAPT | |
| SCHEMBL4704001 | 0.88 | DRD3 (0.55) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL7204441 | 0.87 | DRD3 (0.55) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| SCHEMBL6191945 | 0.87 | DRD3 (0.58) | DRD3DRD2KCNH2HRH1 | |
| SCHEMBL4701331 | 0.86 | DRD3 (0.56) | DRD3DRD2KCNH2KDM4EALDH1A1 | |
| SCHEMBL4701966 | 0.85 | DRD3 (0.56) | DRD3DRD2KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465744-B2 | Triazole compounds and the therapeutic use thereof | ABBOTT GMBH & CO. KG (DE) | 2008-12-16 | — | — | US | disclosed |
| EP-1594861-B1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-06-18 | — | — | EP | disclosed |
| US-20060241137-A1 | Dopamine-D3-receptor antagonists/agonists; high selectivity, bioavailability and high cerebral availability; central nervous system diorders; 2-{3-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]propyl}-7-propionyl-1,2,3,4-tetrahydroisoquinoline | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2006-10-26 | — | — | US | disclosed |
| EP-1594861-A1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | Abbott GmbH & Co. KG (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069830-A1 | TRIAZOLE COMPOUNDS AND THE THERAPEUTIC USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241137-A1 | Dopamine-D3-receptor antagonists/agonists; high selectivity, bioavailability and high cerebral availability; central nervous system diorders; 2-{3-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio]propyl}-7-propionyl-1,2,3,4-tetrahydroisoquinoline | DRD3, SLC6A3, ADORA3 | DRD3 1/4885DRD2 4/4885KCNH2 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.