Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 18/20 | 0.47 |
| ▸ | DRD2 | P14416 | 14/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387104 | 0.90 | DRD3 (0.59) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4387400 | 0.87 | DRD3 (0.48) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4380355 | 0.86 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4383491 | 0.86 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4385545 | 0.86 | DRD3 (0.47) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4705240 | 0.82 | DRD3 (0.58) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4701185 | 0.81 | DRD3 (0.57) | DRD3DRD2KCNH2HRH1KDM4E | |
| SCHEMBL4703079 | 0.81 | DRD3 (0.59) | DRD3DRD2KCNH2ALDH1A1POLB | |
| SCHEMBL4704001 | 0.79 | DRD3 (0.55) | DRD3DRD2KCNH2HRH1KDM4E | |
| Oxalic Acid SCHEMBL7204441 | 0.79 | DRD3 (0.55) | DRD3DRD2KCNH2HRH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144405-B1 | TRIAZOLE COMPOUNDS WITH DOPAMINE-D3-RECEPTOR AFFINITY | ABBOTT GMBH & CO KG (DE) | 2009-11-25 | — | — | EP | claimed |