Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385993 | 0.90 | L3MBTL1 (0.48) | L3MBTL1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4380484 | 0.88 | ALDH1A1 (0.42) | L3MBTL1CNR2SMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL4386658 | 0.86 | L3MBTL1 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL4380714 | 0.86 | HDAC4 (0.44) | CNR2SMN1; SMN2ALDH1A1KDM4ETHRB | |
| SCHEMBL4385012 | 0.85 | L3MBTL1 (0.39) | L3MBTL1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4384837 | 0.84 | L3MBTL1 (0.44) | L3MBTL1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4387620 | 0.83 | L3MBTL1 (0.43) | L3MBTL1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4379801 | 0.83 | L3MBTL1 (0.43) | L3MBTL1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4394063 | 0.82 | L3MBTL1 (0.43) | L3MBTL1CNR2SMN1; SMN2POLBRECQL | |
| SCHEMBL4381992 | 0.82 | PTPN1 (0.41) | SMN1; SMN2ALDH1A1KDM4ECYP1A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1704856-A1 | HSP90 FAMILY PROTEIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | L3MBTL1 3218/4885CNR2 1898/4885SMN1; SMN2 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.