Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 19/20 | 0.59 |
| ▸ | FNTB | P49356 | 19/20 | 0.59 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373745 | 0.90 | FNTA (0.73) | FNTAFNTBPGGT1B | |
| SCHEMBL4375553 | 0.89 | FNTA (0.58) | FNTAFNTBPGGT1B | |
| SCHEMBL4373759 | 0.83 | FNTA (0.81) | FNTAFNTBPGGT1BOPRK1 | |
| SCHEMBL4374148 | 0.76 | FNTA (0.63) | FNTAFNTBPGGT1B | |
| SCHEMBL4372103 | 0.74 | FNTA (1.00) | FNTAFNTBPGGT1BOPRK1 | |
| SCHEMBL4372062 | 0.74 | OPRK1 (0.42) | FNTAFNTBPGGT1BOPRK1PDE4D | |
| SCHEMBL4380041 | 0.72 | FNTA (0.79) | FNTAFNTBPGGT1BOPRK1 | |
| SCHEMBL3365490 | 0.69 | FNTA (0.80) | FNTAFNTBPGGT1B | |
| SCHEMBL4374336 | 0.67 | FNTA (0.61) | FNTAFNTBPGGT1BOPRK1PDE4D | |
| SCHEMBL4382829 | 0.66 | FNTA (0.62) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |