Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 17/20 | 0.63 |
| ▸ | FNTB | P49356 | 17/20 | 0.63 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382829 | 0.90 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL4381345 | 0.85 | FNTA (0.83) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL4372579 | 0.80 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL4370606 | 0.77 | FNTA (0.46) | FNTAFNTBCYP3A4 | |
| SCHEMBL4372438 | 0.77 | FNTA (1.00) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL4380951 | 0.76 | FNTA (0.59) | FNTAFNTBPGGT1B | |
| SCHEMBL13501489 | 0.74 | FNTA (0.62) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL4373656 | 0.74 | FNTA (0.82) | FNTAFNTBPGGT1B | |
| SCHEMBL13501477 | 0.74 | FNTA (0.62) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL4377044 | 0.73 | FNTA (0.42) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339709-B1 | FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-24 | — | — | EP | disclosed |
| US-7153958-B2 | Farnesyl transferase inhibiting benzoheterocyclic derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-26 | — | — | US | disclosed |