Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672377 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBL3MBTL1LMNAHPGD | |
| SCHEMBL29826894 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBL3MBTL1LMNAHPGD | |
| SCHEMBL2006475 | 0.75 | ALDH1A1 (0.75) | AXLALDH1A1POLBHPGDMEN1 | |
| Formic Acid Methyl Ester SCHEMBL28167664 | 0.74 | AXL (0.81) | AXLALDH1A1POLBL3MBTL1LMNA | |
| Formic Acid SCHEMBL28411328 | 0.74 | AXL (0.81) | AXLALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL74023 | 0.74 | AXL (1.00) | AXLALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL30235444 | 0.74 | AXL (1.00) | AXLALDH1A1POLBL3MBTL1LMNA | |
| SCHEMBL7066063 | 0.68 | MEN1 (0.59) | AXLALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2731348 | 0.68 | KDM4E (0.58) | AXLALDH1A1POLBLMNAHPGD | |
| SCHEMBL12386986 | 0.66 | ALDH1A1 (0.68) | ALDH1A1POLBL3MBTL1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |