SCHEMBL2731348

SCHEMBL2731348

COc1ccc2[nH]c(=O)c(C=O)cc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.58
ALDH1A1 P00352 7/20 0.58
GAA P10253 5/20 0.58
POLB P06746 2/20 0.58
AXL P30530 1/20 0.54
PDGFRB P09619 1/20 0.53
PDGFRA P16234 1/20 0.53
MAPT P10636 7/20 0.52
NPC1 O15118 2/20 0.52
APAF1 O14727 2/20 0.52
ALOX15 P16050 2/20 0.52
CASP1 P29466 2/20 0.52
CASP7 P55210 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
HSD17B10 Q99714 2/20 0.52
MAPK1 P28482 1/20 0.52
CYP1A2 P05177 1/20 0.51
CYP2C19 P33261 1/20 0.51
CA2 P00918 1/20 0.50
ALOX12 P18054 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1039269 0.88 KDM4E (0.51) KDM4EALDH1A1GAAPOLBPDGFRB
SCHEMBL29956595 0.88 KDM4E (0.51) KDM4EALDH1A1GAAPOLBPDGFRB
SCHEMBL4397800 0.86 KDM4E (0.57) KDM4EALDH1A1GAAPOLBAXL
SCHEMBL29955116 0.84 HSD17B10 (0.59) KDM4EALDH1A1GAAPDGFRBPDGFRA
SCHEMBL92643 0.79 AXL (0.59) KDM4EALDH1A1GAAPOLBAXL
SCHEMBL29953506 0.79 AXL (0.59) KDM4EALDH1A1GAAPOLBAXL
SCHEMBL4106429 0.79 DAO (0.60) KDM4EALDH1A1GAAPOLBPDGFRB
SCHEMBL9269640 0.79 AXL (0.64) KDM4EALDH1A1GAAPOLBAXL
SCHEMBL30293236 0.78 KDM4E (0.61) KDM4EALDH1A1GAAPOLBAXL
SCHEMBL29955231 0.78 GRIN2D (0.56) KDM4EALDH1A1GAAMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015337-A1 COMPOUNDS FOR TREATMENT A CORONAVIRUS INFECTION TRAWSFYNYDD THERAPEUTICS INC (US) 2026-01-15 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-20200115343-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2020-04-16 US disclosed
US-20200115343-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2020-04-16 US disclosed
US-10577329-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors FORMA THERAPEUTICS, INC. (US) 2020-03-03 US disclosed
US-10577329-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors FORMA THERAPEUTICS, INC. (US) 2020-03-03 US disclosed
US-20190210970-A1 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2019-07-11 US disclosed
US-20190210970-A1 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2019-07-11 US disclosed
US-20190202790-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2019-07-04 US disclosed
US-20190202790-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2019-07-04 US disclosed
US-20160083349-A1 PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS FORMA THERAPEUTICS, INC. 2016-03-24 US disclosed
US-20150094348-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CT CARDIOLOGICO MONZINO S P A (IT) 2015-04-02 US disclosed
US-20150094348-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CT CARDIOLOGICO MONZINO S P A (IT) 2015-04-02 US disclosed
EP-2635275-B1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CT CARDIOLOGICO MONZINO SPA (IT) 2014-08-06 EP disclosed
EP-2635275-B1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CT CARDIOLOGICO MONZINO SPA (IT) 2014-08-06 EP disclosed
US-20140148472-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CENTRO CARDIOLOGICO MONZINO SPA (IT) 2014-05-29 US disclosed
US-20140148472-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF CENTRO CARDIOLOGICO MONZINO SPA (IT) 2014-05-29 US disclosed
EP-2635275-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF Centro Cardiologico Monzino SpA (IT) 2013-09-11 EP disclosed
WO-2012059869-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF UNIVERSITA' DEGLI STUDI DI MILANO (IT) 2012-05-10 WO disclosed
WO-2012059869-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF UNIVERSITA' DEGLI STUDI DI MILANO (IT) 2012-05-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148472-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF GPR65, GPR17, GPR27 KDM4E 4430/4885ALDH1A1 1322/4885GAA 1627/4885
US-20190202790-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH1, IDH3A, IDH3B KDM4E 1593/4885ALDH1A1 554/4885GAA 996/4885
US-20150094348-A1 GPR17-MODULATING COMPOUNDS, DIAGNOSTIC AND THERAPEUTIC USES THEREOF GPR65, GPR17, GPR27 KDM4E 4430/4885ALDH1A1 1322/4885GAA 1627/4885
US-20260015337-A1 COMPOUNDS FOR TREATMENT A CORONAVIRUS INFECTION ACE2, ACE, TMPRSS2 KDM4E 3009/4885ALDH1A1 2439/4885GAA 1322/4885
US-10577329-B2 Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors IDH1, IDH3A, IDH3B KDM4E 1593/4885ALDH1A1 554/4885GAA 996/4885
US-20190210970-A1 PHENYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH1, IDH2, IDH3A KDM4E 438/4885ALDH1A1 200/4885GAA 243/4885
US-20160083349-A1 PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH3A, IDH1, IDH2 KDM4E 1995/4885ALDH1A1 461/4885GAA 2153/4885
US-20200115343-A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS IDH1, IDH3A, IDH3B KDM4E 1593/4885ALDH1A1 554/4885GAA 996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.