Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GNG2 | P59768 | 2/20 | 0.37 |
| ▸ | GNB1 | P62873 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439579 | 0.81 | NR4A2 (0.65) | NR4A2KDM4ETDP1NCF1LMNA | |
| SCHEMBL438193 | 0.81 | NR4A2 (0.51) | NR4A2KDM4ETDP1NCF1ALDH1A1 | |
| SCHEMBL6588144 | 0.81 | NR4A2 (0.60) | NR4A2KDM4ETDP1NCF1ALDH1A1 | |
| SCHEMBL11941841 | 0.77 | OPRK1 (0.52) | KDM4ETDP1LMNACASP2ALDH1A1 | |
| SCHEMBL438224 | 0.77 | NR4A2 (0.69) | NR4A2KDM4ETDP1NCF1LMNA | |
| SCHEMBL26535237 | 0.77 | CCR1 (0.58) | NR4A2KDM4ETDP1NCF1LMNA | |
| SCHEMBL9890979 | 0.74 | LMNA (0.55) | KDM4ELMNACASP2ALDH1A1GAA | |
| SCHEMBL441540 | 0.74 | NR4A2 (0.51) | NR4A2KDM4ETDP1NCF1ALDH1A1 | |
| SCHEMBL439768 | 0.74 | NR4A2 (0.65) | NR4A2KDM4ETDP1NCF1LMNA | |
| SCHEMBL15576630 | 0.74 | LMNA (0.48) | NR4A2KDM4ETDP1LMNACASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |