Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 7/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 7/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394430 | 0.87 | ALDH1A1 (0.46) | ALDH1A1TDP1DRD2KMT2ADRD4 | |
| SCHEMBL4386243 | 0.76 | MAPK1 (0.44) | KDM4ETDP1KMT2A | |
| SCHEMBL4379702 | 0.76 | EGFR (0.44) | KDM4EALDH1A1MEN1KMT2AHSD11B1 | |
| SCHEMBL4384593 | 0.76 | KMT2A (0.51) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3334496 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1TDP1HDAC2CA12 | |
| SCHEMBL3329378 | 0.75 | KDM4E (0.63) | KDM4EALDH1A1TDP1HDAC2CA12 | |
| SCHEMBL4386467 | 0.74 | MAPT (0.55) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8167178 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1TDP1HDAC2CA12 | |
| SCHEMBL8235906 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1TDP1HDAC2CA12 | |
| SCHEMBL3334438 | 0.73 | KDM4E (0.69) | KDM4EALDH1A1TDP1HDAC2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1704856-A1 | HSP90 FAMILY PROTEIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | KDM4E 3223/4885ALDH1A1 3520/4885TDP1 2978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.