Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | CDC7 | O00311 | 7/20 | 0.51 |
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.51 |
| ▸ | PIM1 | P11309 | 5/20 | 0.51 |
| ▸ | PRKACA | P17612 | 5/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 5/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.50 |
| ▸ | CDK9 | P50750 | 5/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.50 |
| ▸ | PAK4 | O96013 | 4/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.50 |
| ▸ | CLK2 | P49760 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888061 | 0.82 | CDC7 (0.56) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL4382843 | 0.77 | AKT1 (0.64) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL20561993 | 0.76 | CDC7 (0.54) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL14620845 | 0.76 | CAMKK2 (0.62) | CDC7CDK2ROCK2MAP4K4PIM1 | |
| SCHEMBL4376704 | 0.76 | MAP3K5 (0.59) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL12280798 | 0.76 | CDC7 (0.64) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL12281270 | 0.75 | PDPK1 (0.48) | AKT1CDC7CDK2ROCK2MAP4K4 | |
| SCHEMBL12280793 | 0.75 | PDPK1 (0.49) | CDC7CDK2ROCK2MAP4K4PIM1 | |
| SCHEMBL12321655 | 0.74 | CDC7 (0.51) | CDC7CDK2ROCK2MAP4K4PIM1 | |
| SCHEMBL4789520 | 0.74 | PDPK1 (0.58) | CDC7CDK2MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |