Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 7/20 | 0.58 |
| ▸ | CDK9 | P50750 | 6/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474062 | 0.83 | PDPK1 (0.63) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL23163201 | 0.83 | ROCK1 (0.61) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL23163147 | 0.82 | CDK9 (0.57) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL4789848 | 0.81 | ROCK1 (0.59) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL12281263 | 0.78 | CDK9 (0.53) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL13887963 | 0.77 | ROCK1 (0.76) | CCNA2CDK2CDK5CDK5R1ROCK1 | |
| SCHEMBL23163770 | 0.77 | ROCK1 (0.54) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL12280793 | 0.77 | PDPK1 (0.49) | PDPK1CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL23163163 | 0.77 | ROCK1 (0.55) | PDPK1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL23163165 | 0.77 | ROCK1 (0.55) | PDPK1CCNA2CDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552019-B2 | Inhibitors of phosphoinositide dependent kinase 1 (PDK1) | MERCK SHARP & DOHME CORP. (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552019-B2 | Inhibitors of phosphoinositide dependent kinase 1 (PDK1) | MERCK SHARP & DOHME CORP. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20110230500-A1 | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) | MERCK SHARP & DOHME CORP. | 2011-09-22 | — | — | US | disclosed |
| US-20110230500-A1 | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) | MERCK SHARP & DOHME CORP. | 2011-09-22 | — | — | US | disclosed |
| WO-2010065384-A1 | INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) | MERCK SHARP & DOHME CORP. (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230500-A1 | Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1) | PDK1, PDPK1, PDK3 | PDPK1 2/4885CDK9 54/4885CCNT1 834/4885 |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | PDPK1 382/4885CDK9 338/4885CCNT1 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.