Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.64 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.63 |
| ▸ | CDC7 | O00311 | 7/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.49 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | MELK | Q14680 | 3/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887691 | 0.83 | AKT1 (0.60) | AKT1CAMKK2CDC7MAP4K4CLK4 | |
| SCHEMBL13888061 | 0.80 | CDC7 (0.56) | AKT1CAMKK2CDC7MAP4K4CLK4 | |
| SCHEMBL4584895 | 0.79 | AKT1 (1.00) | AKT1CAMKK2MAP4K4CLK4ROCK2 | |
| SCHEMBL8939866 | 0.78 | CAMKK2 (0.76) | CAMKK2CDC7NEK2PLK1MAP4K4 | |
| SCHEMBL8939859 | 0.78 | CAMKK2 (1.00) | AKT1CAMKK2CDC7NEK2PLK1 | |
| SCHEMBL8241403 | 0.78 | AKT1 (0.74) | AKT1CAMKK2PIM1GSK3BROCK1 | |
| SCHEMBL4376699 | 0.77 | AKT1 (0.63) | AKT1CAMKK2CDC7NEK2PLK1 | |
| SCHEMBL4382849 | 0.77 | AKT1 (0.55) | AKT1CAMKK2CDC7MAP4K4CLK4 | |
| SCHEMBL4593757 | 0.75 | ROCK1 (0.65) | AKT1CAMKK2CDC7MAP4K4CLK4 | |
| SCHEMBL4474000 | 0.75 | ROCK1 (0.60) | AKT1MAP4K4CLK4ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |