⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736365 | 0.82 | — | — | |
| SCHEMBL6402841 | 0.68 | ALDH1A1 (0.31) | — | |
| SCHEMBL15743183 | 0.61 | MAT2A (0.37) | — | |
| SCHEMBL1231792 | 0.55 | ATAD2 (0.37) | — | |
| SCHEMBL22008 | 0.55 | — | — | |
| SCHEMBL2852189 | 0.55 | ALDH1A1 (0.32) | — | |
| Water SCHEMBL28196064 | 0.54 | ATAD2 (0.35) | — | |
| Hydrochloric Acid SCHEMBL2199283 | 0.54 | ATAD2 (0.35) | — | |
| SCHEMBL18325718 | 0.53 | MAT2A (0.37) | — | |
| SCHEMBL10481862 | 0.52 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155695-B1 | Use of a 1,3 oxathiolane nucleoside analogue in the manufacture of a medicament for specific administration | SHIRE CANADA INC (CA) | 2009-11-18 | — | — | EP | disclosed |
| US-20070037977-A1 | Substituted-1, 3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties | BELLEAU BERNARD | 2007-02-15 | — | — | US | disclosed |
| US-20070037975-A1 | Substituted-1,3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties | BELLEAU BERNARD | 2007-02-15 | — | — | US | disclosed |
| US-7122693-B2 | Acetaldehyde acetal compounds, their synthesis, and uses thereof | SHIRE BIOCHEM INC. (CA) | 2006-10-17 | — | — | US | disclosed |
| US-7119202-B1 | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties | GLAXO WELLCOME INC. (US) | 2006-10-10 | — | — | US | disclosed |
| EP-0515144-B1 | 1,3-Oxathiolanes useful in the treatment of hepatitis | SHIRE BIOCHEM INC (CA) | 2006-06-14 | — | — | EP | disclosed |
| US-6903224-B2 | Substituted 1,3-oxathiolanes | BIOCHEM PHARMA INC. (CA) | 2005-06-07 | — | — | US | disclosed |
| US-20040254201-A1 | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties | BELLEAU BERNARD (CA) | 2004-12-16 | — | — | US | disclosed |
| US-20030087918-A1 | Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties | BIOCHEM PHARMA INC. (CA) | 2003-05-08 | — | — | US | disclosed |
| EP-0526253-B1 | 1,3-Oxathiolane nucleoside analogues | SHIRE BIOCHEM INC (CA) | 2002-11-13 | — | — | EP | disclosed |
| US-6350753-B1 | 2-ACETOXYMETHYL-4-(THYMIN-1'-YL)-1,3,-DIOXOLANE; 2-BENZOYLOXYMETHYL-4-(CYTOSIN-1'-YL)-1,3-DIOXOLANE; ANTIVIRAL AGENTS, PARTICULARY FOR THE TREATMENT OF THE HIV INFECTIONS IN MAMMALS, ESPECIALLY HUMANS | BIOCHEM PHARMA INC. (CA) | 2002-02-26 | — | — | US | disclosed |
| EP-1155695-A1 | 1,3 oxathiolane nucleoside analogues | BIOCHEM PHARMA INC (CA) | 2001-11-21 | — | — | EP | disclosed |
| US-5618820-A | (-)CIS-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLAN-5 YL-(1H)-PYRIMIDINE-2-ONE OR SALT OR ESTER; ADMINISTERING TO TREAT VIRAL INFECTION IN A MAMMAL | BIOCHEM PHARMA, INC. (CA) | 1997-04-08 | — | — | US | disclosed |
| US-5538975-A | (-)-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLAN-5YL) -(1H)-PYRIMIDIN-2-ONE AND DERIVATIVES; ANTIVIRAL AGENT | BIOCHEM PHARMA, INC. (CA) | 1996-07-23 | — | — | US | disclosed |
| US-5486520-A | VIRICIDE | BIOCHEMPHARMA, INC. (CA) | 1996-01-23 | — | — | US | disclosed |
| WO-1993003027-A1 | 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES | BIOCHEM PHARMA INC. (CA) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526253-A1 | 1,3-Oxathiolane nucleoside analogues | BIOCHEM PHARMA INC. (CA) | 1993-02-03 | — | — | EP | disclosed |
| EP-0515144-A1 | 1,3-Oxathiolanes useful in the treatment of hepatitis | BIOCHEM PHARMA INC. (CA) | 1992-11-25 | — | — | EP | disclosed |