Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28673196 | 0.80 | LMNA (0.60) | NR3C2LMNAMAOBEPHX1SIRT2 | |
| SCHEMBL8106477 | 0.75 | NR3C2 (0.42) | KDM4CNR3C2MAOBSMN1; SMN2SIRT2 | |
| SCHEMBL28561124 | 0.75 | TAAR1 (0.57) | NR3C2LMNAMAOBEPHX1SIRT2 | |
| SCHEMBL4388840 | 0.74 | NR2E1 (0.41) | LMNA | |
| SCHEMBL21314979 | 0.73 | KDM4C (0.67) | KDM4CATMCYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL30504022 | 0.73 | KDM4C (0.67) | KDM4CATMCYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL18971775 | 0.72 | KDM4C (0.56) | KDM4CATMLMNAMAOBCYP3A4 | |
| SCHEMBL4383627 | 0.72 | KDM5A (0.46) | KDM4CLMNAMAOBALDH1A1 | |
| SCHEMBL7987563 | 0.72 | LMNA (0.39) | LMNATSHR | |
| Hydrochloric Acid SCHEMBL18940405 | 0.71 | KDM4C (0.55) | KDM4CATMLMNAMAOBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |