Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28561124 | 0.91 | TAAR1 (0.57) | LMNATAAR1HDAC1HDAC8NR3C2 | |
| SCHEMBL4309679 | 0.82 | TAAR1 (0.60) | TAAR1HDAC1HDAC8NR3C2EPHX1 | |
| SCHEMBL27854715 | 0.82 | PRKCA (0.63) | TAAR1EPHX1MAOBIDO1PRKCA | |
| SCHEMBL20705473 | 0.81 | CYP4F2 (0.56) | LMNATAAR1HDAC1HDAC8MAOB | |
| SCHEMBL249437 | 0.81 | EPHX1 (0.61) | TAAR1HDAC1HDAC8NR3C2EPHX1 | |
| SCHEMBL29096879 | 0.80 | ALOX5 (0.46) | LMNATAAR1HDAC1HDAC8NR3C2 | |
| SCHEMBL4383568 | 0.80 | KDM4C (0.51) | LMNANR3C2EPHX1MAOBSIRT2 | |
| SCHEMBL30412030 | 0.79 | EPHX1 (0.59) | TAAR1HDAC1HDAC8NR3C2EPHX1 | |
| SCHEMBL28480435 | 0.79 | LMNA (0.68) | LMNAMAOBGRM2GRM3 | |
| SCHEMBL3692999 | 0.78 | LMNA (0.66) | LMNATAAR1HDAC1HDAC8NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121388-B | Cinacalcet intermediate and synthetic method of cinacalcet hydrochloride | 西华大学 | 2021-11-12 | — | — | CN | disclosed |
| CN-113121388-A | Cinacalcet intermediate and synthetic method of cinacalcet hydrochloride | 西华大学 | 2021-07-16 | — | — | CN | disclosed |